Received: JanuAccepted: MaPublished: April 6, 2018 Small, University of Tennessee, UNITED STATES PLoS Negl Trop Dis 12(4):Įditor: Pamela L. (2018) Anti-O-specific polysaccharide (OSP) immune responses following vaccination with oral cholera vaccine CVD 103-HgR correlate with protection against cholera after infection with wild-type Vibrio cholerae O1 El Tor Inaba in North American volunteers. cholerae OSP, and these responses highly correlate with protection against cholera.Ĭitation: Islam K, Hossain M, Kelly M, Mayo Smith LM, Charles RC, Bhuiyan TR, et al. In summary, vaccination with live attenuated oral cholera vaccine CVD 103-HgR induces antibodies that target V. There was significant negative correlation of OSP responses and post-challenge stool volume, and none of the volunteers who developed an anti-OSP antibody responses of any isotype of ≥1.5 fold developed moderate or severe cholera following experimental challenge. Oral vaccination was associated with the induction of significant IgM and IgA responses against OSP, and these responses correlated with vibriocidal responses. In this study, we assessed adult North American volunteer’s antibody responses targeting OSP after vaccination with live attenuated oral cholera vaccine CVD 103-HgR, and we assessed correlation of protection against cholera with such antibody responses. Despite this, no previous work has directly assessed correlation of OSP-immune responses and protection against cholera. Protective immunity against cholera is serogroup specific, and serogroup specificity is determined by the O-specific polysaccharide (OSP) of V. Cholera is a severe watery diarrheal disease, caused by pathogenic strains of V.
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